Effect of Hepatitis C Virus on patients

Liver cirrhosis has a significant impact on patient’s quality of life and socioeconomic status and is associated with increased susceptibility to vehicle accidents and falls.

Hepatic encephalopathy (HE) represents a major cause of morbidity and mortality in patients suffering from chronic liver diseases. It is characterized by serious neuropsychiatric and neurocognitive complications, including confusion, disorientation, ataxia and coma.

It is characterized by poor health-related quality of life, impaired daily functioning, poor socio-economic status, susceptibility to vehicle accidents and, increased occurrence rate of overt HE, leading to increased mortality in patients with liver cirrhosis. Hence early diagnosis of psychosocial impairment is crucial in cirrhotic patients to prevent further progression and potential life-threatening risk.

Now a day, liver biopsy is the standard method for the detection of liver fibrosis. However, invasiveness is an important drawback in implementing this method particularly in patients with early stages of liver fibrosis as well as sampling error and variability in results interpretation.

Transient Elastography (TE) known by the name FibroScan is a non-invasive test to determine the amount of liver fibrosis present. It also identifies and evaluates steatosis concurrently using the Controlled Attenuation Parameter (CAP). It is a type of elastography.

There is no consensus regarding a standard test for early diagnosis of the neuropsychiatric changes, associated with minimal liver encephalopathy. Indeed, there are several confounding factors which strongly affect patient’s performance in neuropsychiatric tests, including age, gender, level of education and socioeconomic status

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